Gene expression in eukaryotes is governed not only at the level of transcription but also by tightly regulated steps in the translation of mRNA into protein. Control mechanisms span initiation, ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Engineers and biologists at Dartmouth College have found that, just like word order affects meaning in a sentence, the placement of genes within a plasmid—known as gene syntax—can influence how ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...