Recent trends in directed enzyme evolution focus on combining high-throughput screening methods with advanced biophysical tools and data-driven computational approaches. However, these methods pose ...

Researchers from the Manchester Institute of Biotechnology (MIB) have developed a new enzyme engineering platform to improve plastic degrading enzymes through directed evolution. To illustrate the ...

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now ...

Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

Researchers have shown how laboratory evolution can give rise to highly efficient enzymes for new-to-nature reactions, opening the door for novel and more environmentally friendly ways to make drugs ...

In nature, evolution takes years to sculpt new traits. In the lab, scientists hope to achieve this feat much faster: Being able to evolve proteins with enhanced or novel functions has important ...

Scientists have developed a novel approach to modifying enzymes to improve functionality. They designed a new algorithm to make multiple changes to an enzyme sequence at once as compared to the ...

Frances Arnold, 2018 recipient of the Nobel Prize in Chemistry, was presented the Tufts' Department of Chemistry's Max Tishler Award in the Pearson Chemical Laboratory on Thursday. Arnold is the Linus ...

Enzymes evolved to efficiently operate in low-temperature environments via key substitutions of amino acids in their active site, which lowers the activation energy of catalytic reactions. Life has ...