In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes. However, this process is associated with side effects including unwanted mutations ...

A novel genome editing technique, NICER, is based on the creation of multiple nicks in single DNA strands by nickase. The method can correct heterozygous mutations using two mechanisms: multiple nicks ...

PHILADELPHIA— A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach ...

A powerful new approach for the precise, flexible modification of a broad class of chemical compounds called bicyclic aza-arenes—which are commonly used to build drug molecules—has been developed. The ...

Researchers have opened a transformative chapter in agricultural biotechnology by unveiling virus-induced genome editing (VIGE) techniques for Solanaceous crops, a group that includes tomatoes, ...

Functionally relevant changes to cellular genetic code were first observed by exposing cells to radiation or genotoxic chemicals to introduce random mutations. It was later shown that precise genome ...

A team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020. A Penn State-led team of ...

For the first time, scientists have found a way to efficiently and precisely remove genes from white blood cells of the immune system and to insert beneficial replacements, all in far less time than ...