Outcome-adaptive randomization is one of the possible elements of an adaptive trial design in which the ratio of patients randomly assigned to the experimental treatment arm versus the control ...

Covariate-adaptive randomization represents an advanced methodology in the design of clinical trials, ensuring a balanced distribution of prognostic factors among treatment groups. This approach ...

Twice-yearly mass distribution of azithromycin to children is a promising intervention to reduce childhood mortality in sub-Saharan Africa. The World Health Organization recommended restricting ...

High-quality evidence is what we use to guide medical practice. The standard approach to generating this evidence — a series of clinical trials, each investigating one or two interventions in a single ...

Pancreatic cancer is a top cause of cancer death in the United States, where the incidence and death rates are on the rise. Each year, more than 60,000 Americans are diagnosed with pancreatic cancer ...

Response-adaptive designs allow the randomization probabilities to change during the course of a trial based on cumulated response data so that a greater proportion of patients can be allocated to the ...

Pancreatic cancer is a top cause of cancer death in the United States, where the incidence and death rates are on the rise. Each year, more than 60,000 Americans are diagnosed with pancreatic cancer ...