Polygenic scores aim to measure the cumulative effect of multiple genetic variants to make predictions about a person’s health. The most likely areas of potential use are in risk prediction, including ...

The optimism is not unfounded. In specific, well-defined clinical scenarios, polygenic scores are beginning to demonstrate some tangible utility. For cardiovascular disease, MI-GENES, a 10-year follow ...

Advances in genetics have made it possible to analyze thousands of genes at once, producing scores that estimate disease risk with high precision. But are polygenic risk scores ready to transform ...

NEW ORLEANS — Causal artificial intelligence used to augment a polygenic risk score for CAD helped estimate how much individual patients must lower their LDL, systolic BP or both to overcome inherited ...