Drug developers have historically glued their attention to targeting the precise and fine-tuned protein structures underlying biological function. Yet this approach misses over 50% of the human ...
Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...
The Baker lab at the Institute for Protein Design at the University of Washington School of Medicine continues to drive innovation in AI-driven advances for protein design. This time, the team used ...
An MIT-developed AI model has designed dozens of lab-confirmed protein binders for targets long considered out of reach, offering a new tool for drug discovery and ...
CHAPEL HILL, NC – Understanding how proteins bend, twist, and shape-shift as they go about their work in cells is enormously important for understanding normal biology and diseases. But a deep ...
A multicolored protein structure is blurred at the edges and comes into focus toward the center. Detail of a protein designed using a tool called ProteinMPNN Credit: Ian C. Haydon/UW Institute for ...
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