Cellular senescence refers to a state of irreversible arrest of cell proliferation. It was first described by Hayflick and colleagues in the 1960s when they observed cessation of cell proliferation ...

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), ...

Our body has evolved to harbour senescent cells for a number of reasons – they’re involved in everything from childbirth to wound healing - iStockphoto At last year’s British Society for Research on ...

Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that protects older people against aspects of aging and a range of diseases. Their findings, which are published in ...

Longevity research always reminds me of the parable of blind men and an elephant. A group of blind men, who’ve never seen an elephant before, each touches a different part of the elephant’s body to ...

In a sterile laboratory, researchers examine petri dishes containing what could be the key to extending human lifespan. These aren’t experimental stem cells or gene therapies, but rather compounds ...

“This work provides new opportunities for the development of the next generation of ChE inhibitors that specifically target AChE and BChE associated with AD pathology.” “This work provides new ...

ROCHESTER, Minn. -- Mayo Clinic researchers and colleagues at the University of Minnesota showed that COVID-19 exacerbates the damaging impact of senescent cells in the body. In preclinical studies, ...

Senolytics are an emerging class of drugs designed to target zombie-like cells that have stopped dividing and build up in the body as we age, and the past few years have seen some exciting discoveries ...

Treatment with senolytics also attenuated the decline in liver, muscle, and kidney function and reduced the damage to these organs in young mice receiving old blood. Moreover, administration of ...