Evaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL BaSyc is ...

Murine Anti-GD2 Monoclonal Antibody 3F8 Combined With Granulocyte-Macrophage Colony-Stimulating Factor and 13-Cis-Retinoic Acid in High-Risk Patients With Stage 4 Neuroblastoma in First Remission We ...

In traditional schedule or dose–schedule finding designs, patients are assumed to receive their assigned dose–schedule combination throughout the trial even though the combination may be found to have ...

This phase 1 trial utilising a Bayesian continual reassessment method evaluated bortezomib and sunitinib to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and recommended ...

Company to Demonstrate Latest Advancements in Causal Machine Learning and AI for Trial Design and Predictive Analysis for Clinical Trial Success BOSTON, March 24, 2025 /PRNewswire/ -- PhaseV, a leader ...

An innovative approach to a phase II clinical trial aims to test the effects of multiple targeted treatments simultaneously in participants in the UK National Lung Matrix Trial. The design makes it ...

The US Food and Drug Administration (FDA) last week finalized guidance on adaptive clinical trial designs for drugs and biologics. The 33-page guidance, which finalizes a draft version released for ...

Projecting Individualized Probabilities of Developing Bladder Cancer in White Individuals Phase I clinical trials of new anticancer therapies determine suitable doses for further testing. Optimization ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 37 (September 13, 2011), pp. 15190-15195 (6 pages) Here we introduce a new design framework for synthetic ...

Barcelona-- The largest stratified medicine dataset of non-small cell lung cancer patients indicates further molecular stratifications could benefit from targeted therapies, according to research ...