It’s one of life’s most defining moments—that crucial step in embryonic development, when an indistinct ball of cells rearranges itself into the orderly three-layered structure that sets the stage for ...

Now, a new study reveals that this pivotal step in human development is guided by a precise interplay between chemical signals and physical forces. Published in Cell Stem Cell, the paper introduces a ...

Scientists revise the current textbook knowledge about gastrulation, the formation of the basic body plan during embryonic development. Their study in mice has implications for cell replacement ...

A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development. When the zygote, or the fertilised egg, starts to develop, ...

Gastrulation, a prerequisite for organogenesis, begins with the formation of the primitive streak (PS), where epiblast cells experience an epithelial-to-mesenchymal transition (EMT) to exit the ...

In vivo model systems are essential to study the various roles of this fascinating family of proteins in vertebrates. Among them, the zebrafish offers a number of advantages, for example, rapid ...

Platelet-derived growth factor (PDGF) signaling is essential for processes involving cell motility and differentiation during embryonic development in a wide variety of organisms including the mouse, ...

Alaniz Emig A, Williams MLK. Generation of Naïve Blastoderm Explants from Zebrafish Embryos. J Vis Exp. 2021 Jul 30;(173). doi: 10.3791/62797. PMID: 34398141. View article Williams ML, Solnica-Krezel ...

The mechanisms used by embryos to pattern tissues across their axes has fascinated developmental biologists since the founding of embryology. Here, using single-cell technology, we interrogate complex ...

Gastrulation is the formation of the three principal germ layers - endoderm, mesoderm and ectoderm. Understanding the formation of the basic body plan is not only important to reveal how the ...