PcG and trxG genes comprise a maintenance system for gene expression. PcG repression is targeted to silent genes, suggesting that these proteins differentiate between active and inactive states; PcG ...
p53 regulates transcription via two functionally specialized transactivation domains. p53 recognizes its DNA response elements by an elaborate mechanism involving a sequence-specific core DNA-binding ...
This is a preview. Log in through your library . Abstract MicroRNAs (miRNAs) are noncoding RNAs that base pair imperfectly to homologous regions in target mRNAs and negatively influence the synthesis ...
WEST LAFAYETTE, Ind. - A Purdue University study pinpointed an epigenetic mechanism that is a key factor in how genes are switched on and off. Both genetic and epigenetic mechanisms regulate human ...
Collaborating scientists from the Wistar Institute in Philadelphia and the Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the ...
Juvenile hormone (JH) represses precocious metamorphosis of larval to pupal and adult transitions in holometabolous insects. The early JH-inducible gene Krüppel homolog 1 (Kr-h1) plays a key role in ...
Latest discovery could improve development of future stem cell therapies and cancer treatments. Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene ...
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