A variety of genetic diseases are caused by ‘nonsense’ mutations that change a sense codon to a premature termination codon (PTC), causing early termination of protein synthesis. Nonsense suppression, ...
(A) Suppressor tRNA readthrough strategy. Natural tRNAs with engineered anticodons are charged with canonical amino acids to enable readthrough of the premature termination codon (PTC). (B) Unnatural ...
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